小鼠免疫反应中的品系差异。I. 对绵羊红细胞的新生反应。
Strain differences in the immune response of mice. I. The neonatal response to sheep red cells.
作者信息
Playfair J H
出版信息
Immunology. 1968 Jul;15(1):35-50.
Abstract
Neonatal mice of the inbred strains NZB, Balb/c and C57B1 were injected with sheep, pig or chicken red cells at various ages and antibody plaque-forming cell (PFC) responses in their spleens measured. Marked strain differences were found, notably a high early response by NZB mice to sheep cells. Hybrid and backcross experiments suggested that this was genetically controlled by at least three genes. C57B1 mice were late in developing a response to all of the antigens tested. The kinetics of the PFC responses were interpreted as favouring an explanation not involving cell division in response to antigen. Thymectomy at birth reduced the PFC responses in 1-month-old mice of all three strains to the same low level, while thymectomy after 7 days left the PFC responses intact. It is argued that the thymus must be present for strain-specific immune responses to develop.
摘要
将近交系NZB、Balb/c和C57B1的新生小鼠在不同年龄注射绵羊、猪或鸡的红细胞，并检测其脾脏中抗体形成细胞（PFC）反应。发现了明显的品系差异，特别是NZB小鼠对绵羊细胞有较高的早期反应。杂交和回交实验表明，这至少受三个基因的遗传控制。C57B1小鼠对所有测试抗原的反应发展较晚。PFC反应的动力学被解释为支持一种不涉及抗原刺激下细胞分裂的解释。出生时进行胸腺切除会使所有三个品系1月龄小鼠的PFC反应降低到相同的低水平，而7天后进行胸腺切除则PFC反应不受影响。有人认为，胸腺必须存在才能形成品系特异性免疫反应。
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本文引用的文献
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STUDIES ON IMMUNOLOGIC RECONSTITUTION OF THYMECTOMIZED MICE.胸腺切除小鼠免疫重建的研究
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[LESIONS SUGGESTING AN AUTOIMMUNE REACTIVITY IN MICE WITH "RUNT DISEASE" AFTER NEONATAL THYMECTOMY].[新生期胸腺切除后出现“侏儒病”的小鼠中提示自身免疫反应性的病变]
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