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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Partridge N A, Regnier F E, Reed W M, White J L, Hem S L

Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana 47907.

Clin Sci (Lond). 1992 Oct;83(4):425-30. doi: 10.1042/cs0830425.

Rat gut perfusion studies in vivo at pH 4, 6 or 8 using aluminium chloride or equimolar aluminium chloride and sodium citrate showed that elevated plasma aluminium concentrations were associated with aluminium solubility in the perfusion. Elevated plasma aluminium levels and soluble aluminium in the perfusate occurred with perfusion of equimolar aluminium chloride and sodium citrate at all three pH values. 2. Partitioning studies in vitro, utilizing water and ethyl acetate, revealed that uncomplexed aluminium exhibited maximum partitioning into the ethyl acetate phase at pH 2.5. When complexed with citrate, aluminium exhibited partitioning over a much broader pH range, pH 2.5-8.0. 3. A direct linear relationship was observed between the soluble aluminium concentration of the perfusate and the increase in the plasma aluminium level, suggesting that soluble aluminium is absorbed by a passive diffusion mechanism.

在体内使用氯化铝或等摩尔的氯化铝与柠檬酸钠在pH值为4、6或8的条件下进行大鼠肠道灌注研究，结果表明血浆铝浓度升高与灌注中铝的溶解度相关。在所有三个pH值下，用等摩尔的氯化铝和柠檬酸钠灌注时，血浆铝水平升高且灌注液中出现可溶性铝。2. 利用水和乙酸乙酯进行的体外分配研究表明，未络合的铝在pH 2.5时在乙酸乙酯相中的分配最大。当与柠檬酸盐络合时，铝在更宽的pH范围内（pH 2.5 - 8.0）表现出分配。3. 在灌注液的可溶性铝浓度与血浆铝水平的升高之间观察到直接的线性关系，表明可溶性铝通过被动扩散机制被吸收。

Partridge N A, Regnier F E, Reed W M, White J L, Hem S L

Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana 47907.

Clin Sci (Lond). 1992 Oct;83(4):425-30. doi: 10.1042/cs0830425.

Rat gut perfusion studies in vivo at pH 4, 6 or 8 using aluminium chloride or equimolar aluminium chloride and sodium citrate showed that elevated plasma aluminium concentrations were associated with aluminium solubility in the perfusion. Elevated plasma aluminium levels and soluble aluminium in the perfusate occurred with perfusion of equimolar aluminium chloride and sodium citrate at all three pH values. 2. Partitioning studies in vitro, utilizing water and ethyl acetate, revealed that uncomplexed aluminium exhibited maximum partitioning into the ethyl acetate phase at pH 2.5. When complexed with citrate, aluminium exhibited partitioning over a much broader pH range, pH 2.5-8.0. 3. A direct linear relationship was observed between the soluble aluminium concentration of the perfusate and the increase in the plasma aluminium level, suggesting that soluble aluminium is absorbed by a passive diffusion mechanism.

在体内使用氯化铝或等摩尔的氯化铝与柠檬酸钠在pH值为4、6或8的条件下进行大鼠肠道灌注研究，结果表明血浆铝浓度升高与灌注中铝的溶解度相关。在所有三个pH值下，用等摩尔的氯化铝和柠檬酸钠灌注时，血浆铝水平升高且灌注液中出现可溶性铝。2. 利用水和乙酸乙酯进行的体外分配研究表明，未络合的铝在pH 2.5时在乙酸乙酯相中的分配最大。当与柠檬酸盐络合时，铝在更宽的pH范围内（pH 2.5 - 8.0）表现出分配。3. 在灌注液的可溶性铝浓度与血浆铝水平的升高之间观察到直接的线性关系，表明可溶性铝通过被动扩散机制被吸收。