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MM 46115，一种来自佩氏马杜拉放线菌的新型抗病毒抗生素。产生菌培养物的特性、发酵、分离、理化性质及生物学特性

MM 46115, a new antiviral antibiotic from Actinomadura pelletieri. Characteristics of the producing cultures, fermentation, isolation, physico-chemical and biological properties.

作者信息

Ashton R J, Kenig M D, Luk K, Planterose D N, Scott-Wood G

机构信息

SmithKline-Beecham-Pharmaceuticals, Epsom, Surrey, UK.

出版信息

J Antibiot (Tokyo). 1990 Nov;43(11):1387-93. doi: 10.7164/antibiotics.43.1387.

DOI:10.7164/antibiotics.43.1387
PMID:2177052
Abstract

Six strains of Actinomadura pelletieri were shown to produce a novel macrolide antibiotic, designated MM 46115. MM 46115 was active against parainfluenza virus 1 and 2 and Gram-positive bacteria. Methods are described for the production of MM 46115 by strain IP 729.63, and for the isolation of the compound from a butanol extract of the culture filtrate.

摘要

已证明六株佩氏马杜拉放线菌能产生一种新型大环内酯抗生素，命名为MM 46115。MM 46115对1型和2型副流感病毒以及革兰氏阳性菌具有活性。本文描述了菌株IP 729.63生产MM 46115的方法，以及从培养滤液的丁醇提取物中分离该化合物的方法。

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