Ashton R J, Kenig M D, Luk K, Planterose D N, Scott-Wood G
SmithKline-Beecham-Pharmaceuticals, Epsom, Surrey, UK.
J Antibiot (Tokyo). 1990 Nov;43(11):1387-93. doi: 10.7164/antibiotics.43.1387.
Six strains of Actinomadura pelletieri were shown to produce a novel macrolide antibiotic, designated MM 46115. MM 46115 was active against parainfluenza virus 1 and 2 and Gram-positive bacteria. Methods are described for the production of MM 46115 by strain IP 729.63, and for the isolation of the compound from a butanol extract of the culture filtrate.
已证明六株佩氏马杜拉放线菌能产生一种新型大环内酯抗生素,命名为MM 46115。MM 46115对1型和2型副流感病毒以及革兰氏阳性菌具有活性。本文描述了菌株IP 729.63生产MM 46115的方法,以及从培养滤液的丁醇提取物中分离该化合物的方法。