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对编码单纯疱疹病毒1型大被膜蛋白（ICP1/2）的UL36开放阅读框的分析。

Analysis of the UL36 open reading frame encoding the large tegument protein (ICP1/2) of herpes simplex virus type 1.

作者信息

McNabb D S, Courtney R J

机构信息

Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, Shreveport 71130-3932.

出版信息

J Virol. 1992 Dec;66(12):7581-4. doi: 10.1128/JVI.66.12.7581-7584.1992.

DOI:10.1128/JVI.66.12.7581-7584.1992
PMID:1331541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC240474/
Abstract

Using peptide antisera specific for regions within the N terminus and C terminus of the predicted UL36 gene product, immunoblotting experiments were performed to demonstrate definitively that ICP1/2 is encoded by the UL36 gene. These data also suggest that both the cell- and the virion-associated forms of ICP1/2 are colinear with the complete predicted amino acid sequence of the UL36 gene. Computer-assisted analyses of the predicted amino acid sequence of the UL36 gene revealed the presence of two putative leucine zipper-type motifs and a potential ATP-binding domain. The possible functions of these consensus domains will also be discussed.

摘要

利用针对预测的UL36基因产物N端和C端区域的肽抗血清，进行免疫印迹实验以明确证明ICP1/2由UL36基因编码。这些数据还表明，细胞相关和病毒体相关形式的ICP1/2均与UL36基因完整的预测氨基酸序列共线。对UL36基因预测氨基酸序列的计算机辅助分析揭示了两个推定的亮氨酸拉链型基序和一个潜在的ATP结合结构域。还将讨论这些共有结构域的可能功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f9c/240474/5a42719e6329/jvirol00043-0759-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f9c/240474/1c9956b4bb2a/jvirol00043-0758-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f9c/240474/5a42719e6329/jvirol00043-0759-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f9c/240474/1c9956b4bb2a/jvirol00043-0758-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f9c/240474/5a42719e6329/jvirol00043-0759-a.jpg

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本文引用的文献

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J Virol. 1984 Feb;49(2):594-7. doi: 10.1128/JVI.49.2.594-597.1984.
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