Thind P, Lose G, Colstrup H, Andersson K E
Department of Urology, Rigshospitalet, University of Copenhagen, Denmark.
Scand J Urol Nephrol. 1992;26(3):219-25. doi: 10.3109/00365599209180872.
The influence of noradrenaline and prazosin on the urethral closure function was evaluated in 10 healthy female volunteers. Measurements of pressure at varying cross sectional areas were carried out at the bladder neck, in the high pressure zone, and in the distal urethra. Prazosin reduced the static pressure, predominantly in the midportion of the urethra, whereas noradrenaline caused no significant pressure change. The urethral resistance to dilatation and the hysteresis were unaffected by the two agents. It is suggested that the response to prazosin is related to decreased activity of the urethral smooth as well as of the striated muscles, the latter as a result of a reduced somatomotor output from the central nervous system.
在10名健康女性志愿者中评估了去甲肾上腺素和哌唑嗪对尿道闭合功能的影响。在膀胱颈、高压区和尿道远端进行了不同横截面积处的压力测量。哌唑嗪降低了静息压力，主要是在尿道中部，而去甲肾上腺素未引起明显的压力变化。这两种药物对尿道扩张阻力和滞后现象没有影响。有人认为，对哌唑嗪的反应与尿道平滑肌以及横纹肌活动减少有关，后者是由于中枢神经系统体动输出减少所致。
