Thind P, Lose G, Colstrup H, Andersson K E
Department of Urology, Rigshospitalet, University of Copenhagen, Denmark.
Scand J Urol Nephrol. 1995 Mar;29(1):83-91. doi: 10.3109/00365599509180544.
The urethral closure function is based upon permanently as well as adjunctively acting closure forces during rest and stress episodes, respectively. During urine ingression intra- and peri-urethral structures are suddenly stretched resulting in a pressure response which strengthens the closure function by sustaining the resistance to dilatation of the urethra. A method for measurement of the resistance to rapid urethral dilatation was used to evaluate the influence of noradrenaline, prazosin, terbutaline, propranolol, carbachol, and atropine, as well as bilateral pudendal nerve blockades in 40 healthy women. The drugs caused no significant change in the urethral resistance to dilatation, whereas the pudendal blockade produced a significant (p < 0.05) reduction at the bladder neck and in the high pressure zone. Although a quantitative assessment of their contribution cannot be obtained from this study, it may be concluded that the striated muscles innervated by the pudendal nerve are of major importance for the urethral resistance to dilatation.
尿道闭合功能分别基于静息期和应激期的永久性及辅助性闭合力量。在尿液进入时，尿道内和尿道周围结构会突然伸展，从而产生压力反应，该反应通过维持对尿道扩张的阻力来增强闭合功能。采用一种测量尿道快速扩张阻力的方法，评估去甲肾上腺素、哌唑嗪、特布他林、普萘洛尔、卡巴胆碱和阿托品以及双侧阴部神经阻滞对40名健康女性的影响。这些药物未引起尿道扩张阻力的显著变化，而阴部神经阻滞在膀胱颈和高压区产生了显著（p<0.05）降低。尽管本研究无法对它们的作用进行定量评估，但可以得出结论，阴部神经支配的横纹肌对尿道扩张阻力至关重要。
