Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Honke N, Kimura I
Division of Medicine, Okayama University Medical School.
Arerugi. 1992 Sep;41(9):1380-7.
Pathophysiological changes in the airways with aging were examined in 78 patients with bronchial asthma. The FEV1.0% values in patients over the age of 71, and the %MMF, %V50 and %V25 values in those over 51 were significantly lower than those of patients between the ages of 10 and 30. The frequency of lymphocytes in bronchoalveolar lavage (BAL) fluid was significantly higher in patients aged between 61 and 70 than in those aged between 41 and 50 (p < 0.05). The frequency of each clinical asthma type changed with aging; the number of patients with simple bronchoconstriction type (type Ia) decreased with increasing age in patients under the age of 60, and the number of those with bronchiolar obstruction type (type II) increased with aging. The frequency of patients with bronchoconstriction+hypersecretion type (type Ib) showed a peak between the ages of 51 and 60. Bronchial reactivity to methacholine showed a tendency to decrease with aging. The release of histamine from leucocytes induced by Ca ionophore A23187 was significantly higher in patients between the ages of 10 and 30 than in those between the ages of 51 and 60 (p < 0.05) and between 61 and 70 (p < 0.01).
对78例支气管哮喘患者气道随年龄增长的病理生理变化进行了研究。71岁以上患者的FEV1.0%值，以及51岁以上患者的%MMF、%V50和%V25值均显著低于10至30岁患者。61至70岁患者支气管肺泡灌洗（BAL）液中淋巴细胞频率显著高于41至50岁患者（p<0.05）。各临床哮喘类型的频率随年龄变化；60岁以下患者中，单纯支气管收缩型（Ia型）患者数量随年龄增长而减少，细支气管阻塞型（II型）患者数量随年龄增长而增加。支气管收缩+高分泌型（Ib型）患者频率在51至60岁之间出现峰值。支气管对乙酰甲胆碱的反应性有随年龄增长而降低的趋势。钙离子载体A23187诱导的白细胞组胺释放量在10至30岁患者中显著高于51至60岁患者（p<0.05）和61至70岁患者（p<0.01）。
