Okamoto K, Murakami N, Kusaka H, Yoshida M, Hashizume Y, Nakazato Y, Matsubara E, Hirai S
Department of Neurology, Gunma University School of Medicine, Japan.
J Neurol. 1992 Oct;239(8):426-30. doi: 10.1007/BF00856806.
Ubiquitin-positive intraneuronal inclusions were found in the extramotor cortices of ten presenile dementia patients with motor neuron disease. There were inclusions in the hippocampal granular cells and in the small neurons of the superficial layers of the temporal and frontal cortices. Bunina bodies were present in the anterior horn cells in all cases. These results suggest that ubiquitin-related cytoskeletal abnormalities are common in cerebral non-motor small neurons in these patients.
在10例患有运动神经元病的早老性痴呆患者的运动外皮质中发现了泛素阳性的神经元内包涵体。海马颗粒细胞以及颞叶和额叶皮质表层的小神经元中存在包涵体。所有病例的前角细胞中均有布尼纳小体。这些结果表明，泛素相关的细胞骨架异常在这些患者的大脑非运动小神经元中很常见。
