Gallassi R, Montagna P, Ciardulli C, Lorusso S, Mussuto V, Stracciari A
Acta Neurol Scand. 1985 Jun;71(6):480-4. doi: 10.1111/j.1600-0404.1985.tb03231.x.
A systematic investigation of the cognitive functions of 22 patients affected with motor neuron disease (MND) compared to 36 controls matched for age and education was performed. The MND group showed cognitive performances slightly but significantly lower than the control group; 6 MND patients, however, had decidedly pathological values. Cognitive impairment was stereotyped and global, with sparing of memory. There was no significant difference between patients with isolated involvement of the lower motor neuron and those with associated pyramidal involvement. Our neuropsychological findings are in agreement with previous clinical, neuroradiological and pathological reports indicating extra-motor cerebral involvement in MND.
对22例运动神经元病（MND）患者的认知功能进行了系统研究，并与36名年龄和教育程度相匹配的对照组进行了比较。MND组的认知表现略低于对照组，但差异显著；然而，6例MND患者的认知值明显异常。认知障碍是刻板且全面的，记忆功能未受影响。单纯下运动神经元受累的患者与伴有锥体束受累的患者之间无显著差异。我们的神经心理学研究结果与先前的临床、神经放射学和病理学报告一致，表明MND存在运动外的脑受累情况。
