Bestmann H J, Röder T
Institute of Organic Chemistry, University of Erlangen-Nürnberg, FRG.
Eicosanoids. 1992;5 Suppl:S1-3.
Some general synthetic routes for the synthesis of cysteinyl-leukotriene derivatives derived from stable building blocks are described. D6-LTE4, a metabolically stable isotopically labelled mass spectrometric internal standard, 20-hydroxy-LTE4, the unnatural 6-epi-LTE4; LTE3, a LT-derivative with 2-amino-thiophenol as a modified "amino-acid" and 14,15-dehydro-LTA4 were prepared. The compounds were tested in a LT-inhibition assay using a monoclonal antibody.
描述了一些从稳定结构单元合成半胱氨酰白三烯衍生物的一般合成路线。制备了代谢稳定的同位素标记质谱内标D6-LTE4、20-羟基-LTE4、非天然的6-表-LTE4；LTE3，一种以2-氨基硫酚作为修饰“氨基酸”的白三烯衍生物，以及14,15-脱氢-LTA4。使用单克隆抗体在白三烯抑制试验中对这些化合物进行了测试。
