Gerken G, Paterlini P, Kremsdorf D, Petit M A, Manns M, Meyer zum Büschenfelde K H, Brechot C
I. Medizinische Klinik und Poliklinik, Johannes Gutenberg-Universität, Mainz, Federal Republic of Germany.
Arch Virol Suppl. 1992;4:97-101. doi: 10.1007/978-3-7091-5633-9_21.
PCR was evaluated as a clinical tool for use in accurate identification of the specific etiologic agent in chronic HBV carriers. The method was found to be valuable in diagnosis and for monitoring therapy, as well as for elucidation of genotypic variants of HBV in chronic HBV cases. By this means an HBV defective variant with alterations in the preS1/preS2 sequence was detected and is consequently described here.
聚合酶链反应（PCR）作为一种临床工具，用于准确鉴定慢性乙肝病毒携带者中的特定病原体。结果发现该方法在诊断、监测治疗以及阐明慢性乙肝病例中乙肝病毒的基因变异型方面具有重要价值。通过这种方法，检测到一种前S1/前S2序列发生改变的乙肝病毒缺陷变异体，并在此进行描述。
