脱氧肌红蛋白近端组氨酸中 N-δ 质子的体内磁共振波谱灵敏度
Sensitivity of in vivo MRS of the N-delta proton in proximal histidine of deoxymyoglobin.
作者信息
Wang Z, Wang D J, Noyszewski E A, Bogdan A R, Haselgrove J C, Reddy R, Zimmerman R A, Leigh J S
机构信息
Department of Radiology, University of Pennsylvania, Philadelphia 19104.
出版信息
Magn Reson Med. 1992 Oct;27(2):362-7. doi: 10.1002/mrm.1910270217.
The sensitivity of in vivo MRS of the N-delta proton of the proximal histidine of deoxymyoglobin in human skeletal muscles is discussed. Longitudinal relaxation time T1 of this deoxymyoglobin signal was measured in cuffed human forearms at 1.5 T and found to be 9.9 ms. Deoxymyoglobin spectra can be obtained from a forearm in seconds. The detection sensitivity of deoxymyoglobin in fully ischemic skeletal muscles and that of 31P MRS of PCr in normal resting muscles are compared.
本文讨论了人体骨骼肌中脱氧肌红蛋白近端组氨酸的N-δ质子的体内磁共振波谱（MRS）的灵敏度。在1.5T磁场下，对佩戴袖带的人体前臂中该脱氧肌红蛋白信号的纵向弛豫时间T1进行了测量，结果为9.9毫秒。脱氧肌红蛋白光谱可在数秒内从前臂获得。文中比较了完全缺血骨骼肌中脱氧肌红蛋白的检测灵敏度与正常静息肌肉中磷酸肌酸（PCr）的31P MRS的检测灵敏度。
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