Tsui W M, Yuen A K, Ma K F, Tse C C
Institute of Pathology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
Histopathology. 1992 Dec;21(6):569-73. doi: 10.1111/j.1365-2559.1992.tb00446.x.
We report two cases of giant hepatic angiomyolipoma with a prominent component of epithelioid smooth muscle cells exhibiting a distinctive trabecular arrangement. These cells possessed peripherally vacuolated and centrally condensed hyaline cytoplasm. The nuclei were eccentrically placed in the cytoplasm. Immunohistochemically, they expressed HMB-45 intensely in the central condensed cytoplasm and actin in a perimembranous fashion. Staining for desmin, myoglobin and vimentin was negative. HMB-45 may prove to be a sensitive marker for angiomyolipoma with epithelioid cells. Hepatocellular carcinoma and other hepatic tumours with polygonal clear cells can be readily distinguished by these means.
我们报告了两例巨大肝脏血管平滑肌脂肪瘤，其具有显著的上皮样平滑肌细胞成分，呈现出独特的小梁状排列。这些细胞具有周边空泡化和中央凝聚的透明细胞质。细胞核偏心地位于细胞质中。免疫组织化学显示，它们在中央凝聚的细胞质中强烈表达HMB-45，肌动蛋白呈膜周样表达。结蛋白、肌红蛋白和波形蛋白染色均为阴性。HMB-45可能是具有上皮样细胞的血管平滑肌脂肪瘤的敏感标志物。通过这些方法可以很容易地将肝细胞癌和其他具有多边形透明细胞的肝脏肿瘤区分开来。
