皮肤血管平滑肌脂肪瘤：两例报告并着重探讨HMB-45的应用价值
Cutaneous angiomyolipoma: report of two cases with emphasis on HMB-45 utility.
作者信息
Büyükbabani N, Tetikkurt S, Oztürk A S
机构信息
Department of Pathology, Istanbul University, Istanbul School of Medicine, Turkey.
出版信息
J Eur Acad Dermatol Venereol. 1998 Sep;11(2):151-4. doi: 10.1111/j.1468-3083.1998.tb00769.x.
BACKGROUND
Angiomyolipomas are tumors composed of adipose tissue, blood vessels and smooth muscle. Although renal angiomyolipomas are well known, cutaneous tumors have been described only recently. HMB-45 reactivity, reported for renal angiomyolipomas, has been suggested as a useful tool in differential diagnosis.
OBJECTIVE
Two cases of cutaneous angiomyolipoma are described and investigated for HMB-45 reactivity.
METHODS
Conventional histochemical and immunohistochemical methods were used.
RESULTS
Immunohistochemical analysis showed no reactivity for HMB-45 antibody.
CONCLUSION
We conclude that, unlike renal angiomyolipomas, HMB-45 reactivity is not helpful in differentiating cutaneous angiomyolipomas.
背景
血管平滑肌脂肪瘤是由脂肪组织、血管和平滑肌组成的肿瘤。虽然肾血管平滑肌脂肪瘤广为人知，但皮肤肿瘤直到最近才被描述。肾血管平滑肌脂肪瘤中报道的HMB - 45反应性已被认为是鉴别诊断中的一种有用工具。
目的
描述两例皮肤血管平滑肌脂肪瘤病例，并研究其HMB - 45反应性。
方法
采用传统组织化学和免疫组织化学方法。
结果
免疫组织化学分析显示HMB - 45抗体无反应性。
结论
我们得出结论，与肾血管平滑肌脂肪瘤不同，HMB - 45反应性对鉴别皮肤血管平滑肌脂肪瘤并无帮助。
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