环辛他汀，一种由黑色产色链霉菌MI614 - 43F2产生的新型溶血磷脂酶抑制剂。分类、生产、分离、理化性质及生物活性。
Cyclooctatin, a new inhibitor of lysophospholipase, produced by Streptomyces melanosporofaciens MI614-43F2. Taxonomy, production, isolation, physico-chemical properties and biological activities.
作者信息
Aoyagi T, Aoyama T, Kojima F, Hattori S, Honma Y, Hamada M, Takeuchi T
机构信息
Institute of Microbial Chemistry, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1992 Oct;45(10):1587-91. doi: 10.7164/antibiotics.45.1587.
Cyclooctatin has been isolated from Streptomyces melanosporofaciens MI614-43F2 as part of a program designed to find microorganism-produced inhibitors of lysophospholipase. It was purified by chromatography on silica gel, Capcell Pak C18 (HPLC) and Sephadex LH-20 followed by solvent extraction and then isolated as a colorless powder. Cyclooctatin has the molecular formula of C20H34O3. It is competitive with the substrate, and the inhibition constant (Ki) was 4.8 x 10(-6) M.
环辛他汀是从产黑色素链霉菌MI614 - 43F2中分离出来的，这是一项旨在寻找微生物产生的溶血磷脂酶抑制剂计划的一部分。它通过硅胶柱色谱、Capcell Pak C18（高效液相色谱）和Sephadex LH - 20进行纯化，随后进行溶剂萃取，然后分离得到无色粉末。环辛他汀的分子式为C20H34O3。它与底物具有竞争性，抑制常数（Ki）为4.8×10⁻⁶ M。
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