Benadrostin, new inhibitor of poly(ADP-ribose) synthetase, produced by actinomycetes. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.
作者信息
Aoyagi T, Yoshida S, Harada S, Okuyama A, Nakayama C, Yoshida T, Hamada M, Takeuchi T, Umezawa H
机构信息
Institute of Microbial Chemistry, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1988 Aug;41(8):1009-14. doi: 10.7164/antibiotics.41.1009.
PMID:3139601
Abstract
Benadrostin, a new inhibitor of poly(ADP-ribose) synthetase was discovered in the fermentation broth of Streptomyces flavovirens MH499-O'F1. It was purified by chromatography followed by solvent extraction and then isolated as colorless prisms. Benadrostin has the molecular formula of C8H5NO4. It was competitive with the substrate, and the inhibition constant (Ki) was 34 microM.
摘要
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