Wiersbitzky S, Bruns R, Wiersbitzky H
Klinik für Kinder- und Jugendmedizin, Universität Greifswald.
Fortschr Med. 1992 Nov 30;110(33):617-20.
The human herpes virus 6 (HHV 6) may induce not only the wellknown condition of exanthem subitum, but also a number of more common (cf. Part 1) or rare, even previously unknown, clinical manifestations. Part 2 of this paper deals with the more rarely observed manifestations. These include complications of ARD (sinusitis, otitis media, bronchial pneumonia) hepatitis, encephalitis or Pfeiffer's disease (mononucleosis-like syndrome). In individuals with a relevant disposition (genetic HLA/DR type?) initiation or (re-)activation of rheumatoid arthritis (JCA = juvenile chronic arthritis) or chronic iridocyclitis may occur. Although, on account of the high prevalence of vaccination in our population (approximately 95%), prenatal infections are extremely rare, they may manifest in a severe "septic" form (fatalities have occurred) or may lead to neurological deficits (comparable with cytomegalovirus infection). To date, no specific therapy (e.g. gammaglobulin, virostatics) or reliable preventive measures (e.g. vaccination) are available.
人类疱疹病毒6型（HHV 6）不仅可引发众所周知的幼儿急疹，还可导致一些更常见（见第1部分）或罕见的、甚至此前未知的临床表现。本文第2部分论述了较少观察到的临床表现。这些表现包括急性呼吸道疾病（鼻窦炎、中耳炎、支气管肺炎）、肝炎、脑炎或传染性单核细胞增多症样综合征（费弗病）的并发症。在具有相关易感性（基因HLA/DR类型？）的个体中，可能会引发或（再）激活类风湿性关节炎（幼年型慢性关节炎）或慢性虹膜睫状体炎。尽管由于我国人群疫苗接种率较高（约95%），产前感染极为罕见，但此类感染可能表现为严重的“败血症”形式（曾有死亡病例），或导致神经功能缺损（与巨细胞病毒感染类似）。迄今为止，尚无特效疗法（如丙种球蛋白、抗病毒药）或可靠的预防措施（如疫苗接种）。
