Wang J P, Hsu M F, Raung S L, Chen C C, Kuo J S, Teng C M
Department of Medical Research, Taichung Veterans General Hospital, Taiwan, Republic of China.
Naunyn Schmiedebergs Arch Pharmacol. 1992 Dec;346(6):707-12. doi: 10.1007/BF00168746.
Magnolol, isolated from Magnolia officinalis, inhibited mouse hind-paw edema induced by carrageenan, compound 48/80, polymyxin B and reversed passive Arthus reaction. Acetic acid-induced writhing response was depressed by magnolol, indomethacin and ibuprofen. The lethality of endotoxin challenge was reduced by pretreatment with magnolol, indomethacin and BW755C, a dual cyclo-oxygenase/lipoxygenase inhibitor. The recovered myeloperoxidase activity in edematous paw was significantly decreased in mice pretreated with magnolol and BW755C. Suppression of edema was demonstrated not only in normal mice but also in adrenalectomized animals. Magnolol was less potent on reducing PGD2 formation in rat mast cell than that of indomethacin. Unlike dexamethasone, magnolol did not increase liver glycogen level. The results suggest that the anti-inflammatory effect of magnolol was neither mediated by glucocorticoid activity nor through releasing steroid hormones from adrenal gland. The action of magnolol is proposed to be dependent on reducing the level of eicosanoid mediators.
从厚朴中分离得到的厚朴酚可抑制角叉菜胶、化合物48/80、多粘菌素B诱导的小鼠后爪水肿,并逆转被动Arthus反应。厚朴酚、吲哚美辛和布洛芬可抑制乙酸诱导的扭体反应。用厚朴酚、吲哚美辛和双环氧化酶/脂氧合酶抑制剂BW755C预处理可降低内毒素攻击的致死率。用厚朴酚和BW755C预处理的小鼠,水肿爪中恢复的髓过氧化物酶活性显著降低。不仅在正常小鼠中,而且在肾上腺切除的动物中都证实了水肿的抑制作用。厚朴酚在降低大鼠肥大细胞中PGD2形成方面的效力低于吲哚美辛。与地塞米松不同,厚朴酚不会增加肝糖原水平。结果表明,厚朴酚的抗炎作用既不是由糖皮质激素活性介导的,也不是通过从肾上腺释放甾体激素介导的。厚朴酚的作用被认为取决于降低类二十烷酸介质的水平。