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Obovatol and obovatal, novel biphenyl ether lignans from the leaves of Magnolia obovata Thunb.

作者信息

Ito K, Iida T, Ichino K, Tsunezuka M, Hattori M, Namba T

出版信息

Chem Pharm Bull (Tokyo). 1982 Sep;30(9):3347-53. doi: 10.1248/cpb.30.3347.

DOI:10.1248/cpb.30.3347
PMID:7172337
Abstract
摘要

相似文献

1
Obovatol and obovatal, novel biphenyl ether lignans from the leaves of Magnolia obovata Thunb.
Chem Pharm Bull (Tokyo). 1982 Sep;30(9):3347-53. doi: 10.1248/cpb.30.3347.
2
Inhibitory effect of obovatol from Magnolia obovata on the Salmonella type III secretion system.凹叶厚朴中鹅掌楸碱对鼠伤寒沙门氏菌Ⅲ型分泌系统的抑制作用。
J Antibiot (Tokyo). 2017 Nov;70(11):1065-1069. doi: 10.1038/ja.2017.98. Epub 2017 Sep 6.
3
Semisynthesis and biological evaluation of some novel Mannich base derivatives derived from a natural lignan obovatol as potential antifungal agents.某些新型曼尼希碱衍生物的半合成及生物评价，这些衍生物来源于天然木脂素橄榄苦苷，可作为潜在的抗真菌药物。
Bioorg Chem. 2020 Jan;94:103469. doi: 10.1016/j.bioorg.2019.103469. Epub 2019 Nov 23.
4
Obovatol isolated from Magnolia obovata enhances pentobarbital-induced sleeping time: Possible involvement of GABAA receptors/chloride channel activation.从日本厚朴中分离出的辛夷脂素可延长戊巴比妥诱导的睡眠时间：可能与GABAA受体/氯离子通道激活有关。
Phytomedicine. 2009 Apr;16(4):308-13. doi: 10.1016/j.phymed.2008.12.007. Epub 2009 Feb 6.
5
New obovatol trimeric neolignans with NO inhibitory activity from the leaves of Magnolia officinalis var. biloba.从厚朴的叶子中分离得到具有 NO 抑制活性的新八角脂素三聚体新木脂素。
Bioorg Chem. 2020 Mar;96:103586. doi: 10.1016/j.bioorg.2020.103586. Epub 2020 Jan 16.
6
Obovatol from Magnolia obovata inhibits vascular smooth muscle cell proliferation and intimal hyperplasia by inducing p21Cip1.厚朴酚通过诱导 p21Cip1 抑制血管平滑肌细胞增殖和内膜增生。
Atherosclerosis. 2010 Jun;210(2):372-80. doi: 10.1016/j.atherosclerosis.2009.11.037. Epub 2009 Nov 29.
7
Antiplatelet activity of obovatol, a biphenolic component of Magnolia Obovata, in rat arterial thrombosis and rabbit platelet aggregation.厚朴中双酚成分辛弗林对大鼠动脉血栓形成和兔血小板聚集的抗血小板活性。
J Atheroscler Thromb. 2011;18(8):659-69. doi: 10.5551/jat.7427. Epub 2011 Apr 21.
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Increase of collagen synthesis by obovatol through stimulation of the TGF-beta signaling and inhibition of matrix metalloproteinase in UVB-irradiated human fibroblast.奥佛妥因通过刺激转化生长因子-β信号通路并抑制基质金属蛋白酶来增加紫外线照射的人成纤维细胞中的胶原蛋白合成。
J Dermatol Sci. 2007 May;46(2):127-37. doi: 10.1016/j.jdermsci.2007.02.001. Epub 2007 Mar 7.
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Obovatols, new chitin synthase 2 inhibitors of Saccharomyces cerevisiae from Magnolia obovata.倒卵叶木兰中新型酿酒酵母几丁质合成酶2抑制剂倒卵叶木兰醇。
J Antimicrob Chemother. 2002 Jan;49(1):95-101. doi: 10.1093/jac/49.1.95.
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Substituted dineolignans from Magnolia garrettii.从麻栗坡含笑中提取的取代二苯乙烯类木脂素。
J Nat Prod. 2010 Aug 27;73(8):1381-4. doi: 10.1021/np100263e.

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Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light.亚洲和太平洋地区开花植物中的抗菌酚类化合物：渐露端倪。
Pharm Biol. 2024 Dec;62(1):713-766. doi: 10.1080/13880209.2024.2407530. Epub 2024 Oct 11.
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Decorative Magnolia Plants: A Comparison of the Content of Their Biologically Active Components Showing Antimicrobial Effects.观赏木兰植物：具有抗菌作用的生物活性成分含量比较
Plants (Basel). 2020 Jul 11;9(7):879. doi: 10.3390/plants9070879.
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A Comparison between Extract Products of Magnolia officinalis on Memory Impairment and Amyloidogenesis in a Transgenic Mouse Model of Alzheimer's Disease.
厚朴提取物对阿尔茨海默病转基因模型小鼠学习记忆障碍及淀粉样蛋白生成的比较
Biomol Ther (Seoul). 2012 May;20(3):332-9. doi: 10.4062/biomolther.2012.20.3.332.
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Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells.玉兰多酚可减轻神经元和小胶质细胞的氧化应激和炎症反应。
J Neuroinflammation. 2013 Jan 29;10:15. doi: 10.1186/1742-2094-10-15.
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Chemical genetics of neuroinflammation: natural and synthetic compounds as microglial inhibitors.神经炎症的化学遗传学：作为小胶质细胞抑制剂的天然和合成化合物。
Inflammopharmacology. 2012 Jun;20(3):151-8. doi: 10.1007/s10787-011-0108-2. Epub 2011 Dec 22.
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Inhibitors of microglial neurotoxicity: focus on natural products.小胶质细胞神经毒性抑制剂：关注天然产物。
Molecules. 2011 Jan 25;16(2):1021-43. doi: 10.3390/molecules16021021.
7
Obovatol attenuates microglia-mediated neuroinflammation by modulating redox regulation.奥巴他汀通过调节氧化还原调控减轻小胶质细胞介导的神经炎症。
Br J Pharmacol. 2010 Apr;159(8):1646-62. doi: 10.1111/j.1476-5381.2010.00659.x.
8
The inhibitory effect of magnolol on cutaneous permeability in mice is probably mediated by a nonselective vascular hyporeactivity to mediators.厚朴酚对小鼠皮肤通透性的抑制作用可能是由对介质的非选择性血管反应性降低介导的。
Naunyn Schmiedebergs Arch Pharmacol. 1993 Dec;348(6):663-9. doi: 10.1007/BF00167245.
9
Decrease in anti-Proteus mirabilis but not anti-Escherichia coli antibody levels in rheumatoid arthritis patients treated with fasting and a one year vegetarian diet.接受禁食和为期一年素食饮食治疗的类风湿关节炎患者中，抗奇异变形杆菌抗体水平下降，但抗大肠杆菌抗体水平未下降。
Ann Rheum Dis. 1995 Mar;54(3):221-4. doi: 10.1136/ard.54.3.221.
10
Anti-inflammatory and analgesic effects of magnolol.厚朴酚的抗炎和镇痛作用。
Naunyn Schmiedebergs Arch Pharmacol. 1992 Dec;346(6):707-12. doi: 10.1007/BF00168746.