肺炎球菌基因重组的抑制剂。
Inhibitors of genetic recombination in pneumococci.
作者信息
Seto H, Tomasz A
出版信息
Proc Natl Acad Sci U S A. 1977 Jan;74(1):296-9. doi: 10.1073/pnas.74.1.296.
Abstract
Treatment of transformable pneumococci with DNA-intercalating agents shortly after the uptake of DNA molecules inhibited the appearance of genetic transformants. The same drug treatments applied 20 min after DNA uptake were ineffective. Ethidium bromide, proflavin, daunomycin, actinomycin D, and platinum red were found to be effective inhibitors. Donor DNA molecules reisolated from the drug-treated bacteria appeared to be associated with the resident DNA in an abnormal manner, and they had only poor transforming activity.
摘要
在摄取DNA分子后不久用DNA嵌入剂处理可转化肺炎球菌，可抑制遗传转化体的出现。在摄取DNA 20分钟后进行相同的药物处理则无效。已发现溴化乙锭、原黄素、柔红霉素、放线菌素D和铂红是有效的抑制剂。从经药物处理的细菌中重新分离出的供体DNA分子似乎以异常方式与宿主DNA相关联，并且它们的转化活性很差。
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