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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Tokimasa T, Sugiyama K, Akasu T, Muteki T

Department of Physiology, Kurume University School of Medicine, Japan.

Br J Pharmacol. 1990 Sep;101(1):190-2. doi: 10.1111/j.1476-5381.1990.tb12111.x.

Cultured dorsal root ganglion cells of the bullfrog were voltage-clamped in the whole-cell configuration. 2. An adenosine 3':5'-cyclic monophosphate (cyclic AMP)-dependent cationic inward rectifier (IH) was inhibited by bath application of enflurane (0.2-0.8 mM) and halothane (0.2-0.5 mM), which thereby induced an outward current at the resting potential, and a membrane hyperpolarization in unclamped cells. 3. The main effect of enflurane (0.5 mM) was to displace the steady-state IH activation curve to a hyperpolarizing direction by about 10 mV, as well as to reduce the maximum H-conductance to about 20%. 4. Forskolin (1-10 microM), which enhances IH by producing a depolarizing shift in the IH activation curve and increasing the maximum H-conductance, recruited IH even when the current had already been eliminated by enflurane (1 mM).

牛蛙的培养背根神经节细胞采用全细胞模式进行电压钳制。2. 腺苷3':5'-环磷酸（环磷酸腺苷）依赖性阳离子内向整流器（IH）可被浴槽施加的恩氟烷（0.2 - 0.8 mM）和氟烷（0.2 - 0.5 mM）抑制，从而在静息电位诱导外向电流，并使未钳制细胞的膜发生超极化。3. 恩氟烷（0.5 mM）的主要作用是使稳态IH激活曲线向超极化方向移动约10 mV，并将最大H电导降低至约20%。4. 福斯可林（1 - 10 microM）通过使IH激活曲线产生去极化偏移并增加最大H电导来增强IH，即使电流已被恩氟烷（1 mM）消除，仍能募集IH。

Tokimasa T, Sugiyama K, Akasu T, Muteki T

Department of Physiology, Kurume University School of Medicine, Japan.

Br J Pharmacol. 1990 Sep;101(1):190-2. doi: 10.1111/j.1476-5381.1990.tb12111.x.

Cultured dorsal root ganglion cells of the bullfrog were voltage-clamped in the whole-cell configuration. 2. An adenosine 3':5'-cyclic monophosphate (cyclic AMP)-dependent cationic inward rectifier (IH) was inhibited by bath application of enflurane (0.2-0.8 mM) and halothane (0.2-0.5 mM), which thereby induced an outward current at the resting potential, and a membrane hyperpolarization in unclamped cells. 3. The main effect of enflurane (0.5 mM) was to displace the steady-state IH activation curve to a hyperpolarizing direction by about 10 mV, as well as to reduce the maximum H-conductance to about 20%. 4. Forskolin (1-10 microM), which enhances IH by producing a depolarizing shift in the IH activation curve and increasing the maximum H-conductance, recruited IH even when the current had already been eliminated by enflurane (1 mM).

牛蛙的培养背根神经节细胞采用全细胞模式进行电压钳制。2. 腺苷3':5'-环磷酸（环磷酸腺苷）依赖性阳离子内向整流器（IH）可被浴槽施加的恩氟烷（0.2 - 0.8 mM）和氟烷（0.2 - 0.5 mM）抑制，从而在静息电位诱导外向电流，并使未钳制细胞的膜发生超极化。3. 恩氟烷（0.5 mM）的主要作用是使稳态IH激活曲线向超极化方向移动约10 mV，并将最大H电导降低至约20%。4. 福斯可林（1 - 10 microM）通过使IH激活曲线产生去极化偏移并增加最大H电导来增强IH，即使电流已被恩氟烷（1 mM）消除，仍能募集IH。