胰岛素和催乳素对大鼠乳腺丙酮酸脱氢酶的调控
Control of rat mammary-gland pyruvate dehydrogenase by insulin and prolactin.
作者信息
Field B, Coore H G
出版信息
Biochem J. 1976 May 15;156(2):333-7. doi: 10.1042/bj1560333.
Abstract
Withdrawal of prolactin or of insulin from the circulation of lactating rats leads, within 3h, to increased inactivation by phosphorylation of mammary-gland pyruvate dehydrogenase. Prolactin may act by priming the tissue to respond directly to normal concentrations of circulating insulin and by this means be responsible for the increased activation of the enzyme during the course of normal lactation.
摘要
从泌乳大鼠的循环系统中去除催乳素或胰岛素，会在3小时内导致乳腺丙酮酸脱氢酶因磷酸化而增加失活。催乳素可能通过使组织对正常浓度的循环胰岛素做出直接反应来发挥作用，从而在正常泌乳过程中导致该酶的激活增加。
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