大鼠哺乳期胰岛素和去甲肾上腺素在体内激活丙酮酸脱氢酶能力的组织特异性变化。
Tissue-specific changes in the ability of insulin and noradrenaline to activate pyruvate dehydrogenase in vivo during lactation in the rat.
作者信息
Kilgour E, Vernon R G
出版信息
Biochem J. 1987 Apr 1;243(1):69-74. doi: 10.1042/bj2430069.
Abstract
Changes are described in the total pyruvate dehydrogenase (PDH) activity, the proportion of PDH in the active state and its control by insulin and noradrenaline in vivo, in white adipose tissue, liver, skeletal muscle and mammary gland with pregnancy, lactation and on weaning. Lactation resulted in a decrease in total PDH in white adipose tissue and an increase in the mammary gland, whereas the proportion in the active state decreased in muscle and increased in the mammary gland. The ability of insulin to activate PDH of white adipose tissue was lost during lactation, whereas it was retained by the other tissues. The ability of noradrenaline to activate PDH was decreased in white adipose tissue but increased in liver during lactation. These various adaptations should limit the use of glucose and lactate carbon by adipose tissue and skeletal muscle during lactation and thereby facilitate their preferential utilization by the mammary gland.
摘要
本文描述了妊娠、哺乳及断奶时，白色脂肪组织、肝脏、骨骼肌和乳腺中总丙酮酸脱氢酶（PDH）活性、活性状态的PDH比例及其在体内受胰岛素和去甲肾上腺素调控的变化情况。哺乳导致白色脂肪组织中总PDH减少，乳腺中总PDH增加，而活性状态的比例在肌肉中降低，在乳腺中增加。哺乳期白色脂肪组织丧失了胰岛素激活PDH的能力，而其他组织仍保留该能力。哺乳期白色脂肪组织中去甲肾上腺素激活PDH的能力降低，而肝脏中该能力增加。这些不同的适应性变化应会限制哺乳期脂肪组织和骨骼肌对葡萄糖和乳酸碳的利用，从而促进乳腺对它们的优先利用。
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本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Acetate metabolism in lactating sheep.泌乳期绵羊的乙酸代谢
Br J Nutr. 1982 Sep;48(2):319-28. doi: 10.1079/bjn19820116.
3
Effects of pregnancy and sex steroid administration on skeletal muscle metabolism in the rat.妊娠及给予性类固醇对大鼠骨骼肌代谢的影响。
Diabetes. 1981 Jul;30(7):545-50. doi: 10.2337/diab.30.7.545.
4
Prolactin and the regulation of adipose-tissue metabolism during lactation in rats.催乳素与大鼠哺乳期脂肪组织代谢的调节
Mol Cell Endocrinol. 1981 May;22(2):265-75. doi: 10.1016/0303-7207(81)90096-4.
5
In vivo insulin resistance during pregnancy in the rat.大鼠孕期的体内胰岛素抵抗
Diabetologia. 1980;19(6):521-8. doi: 10.1007/BF00253179.
6
Lipogenesis in interscapular brown adipose tissue of virgin, pregnant and lactating rats. The effects of intragastric feeding.处女、怀孕和哺乳期大鼠肩胛间棕色脂肪组织中的脂肪生成。胃内喂养的影响。
Biochem J. 1980 Aug 15;190(2):477-80. doi: 10.1042/bj1900477.
7
Metabolic and feeding patterns: role of sympathetic and parasympathetic efferent pathways.代谢与进食模式：交感和副交感传出通路的作用
J Auton Nerv Syst. 1984 May-Jun;10(3-4):325-35. doi: 10.1016/0165-1838(84)90030-4.
8
Effect of phenylephrine on pyruvate dehydrogenase activity in rat hepatocytes and its interaction with insulin and glucagon.去氧肾上腺素对大鼠肝细胞丙酮酸脱氢酶活性的影响及其与胰岛素和胰高血糖素的相互作用。
FEBS Lett. 1983 Aug 8;159(1-2):83-8. doi: 10.1016/0014-5793(83)80421-9.
9
Pregnancy-induced insulin resistance in the rat: assessment by glucose clamp technique.大鼠孕期诱导的胰岛素抵抗：通过葡萄糖钳夹技术进行评估。
Am J Physiol. 1984 Jan;246(1 Pt 1):E25-31. doi: 10.1152/ajpendo.1984.246.1.E25.
10
Glucose metabolism during lactation in the rat: quantitative and regulatory aspects.大鼠哺乳期的葡萄糖代谢：定量与调节方面
Am J Physiol. 1983 Oct;245(4):E351-8. doi: 10.1152/ajpendo.1983.245.4.E351.
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