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The molecular basis of quinolone action.

作者信息

Maxwell A

机构信息

Department of Biochemistry, University of Leicester, UK.

出版信息

J Antimicrob Chemother. 1992 Oct;30(4):409-14. doi: 10.1093/jac/30.4.409.

DOI:10.1093/jac/30.4.409
PMID:1337067
Abstract
摘要

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The molecular basis of quinolone action.喹诺酮作用的分子基础。
J Antimicrob Chemother. 1992 Oct;30(4):409-14. doi: 10.1093/jac/30.4.409.
2
Topoisomerase IV is a target of quinolones in Escherichia coli.拓扑异构酶IV是喹诺酮类药物在大肠杆菌中的作用靶点。
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[Role of double strand DNA break repair for quinolone sensitivity in Escherichia coli: therapeutic implications].[双链DNA断裂修复对大肠杆菌喹诺酮敏感性的作用：治疗意义]
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Quinolone mode of action--new aspects.喹诺酮类药物的作用模式——新的方面。
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Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action.通过基于喹诺酮类药物的作用模式测量其敏感性来确定喹诺酮类药物的主要靶点以及赋予喹诺酮耐药性的突变的影响。
Antimicrob Agents Chemother. 2007 Sep;51(9):3410-2. doi: 10.1128/AAC.00362-07. Epub 2007 Jul 2.
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Recent developments of quinolone-based derivatives and their activities against Escherichia coli.基于喹诺酮的衍生物的最新发展及其对大肠杆菌的活性。
Eur J Med Chem. 2018 Sep 5;157:1223-1248. doi: 10.1016/j.ejmech.2018.08.095. Epub 2018 Sep 1.
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DNA cloning and organization of the Staphylococcus aureus gyrA and gyrB genes: close homology among gyrase proteins and implications for 4-quinolone action and resistance.金黄色葡萄球菌gyrA和gyrB基因的DNA克隆与组织：促旋酶蛋白间的高度同源性及其对4-喹诺酮作用和耐药性的影响
J Bacteriol. 1990 Jun;172(6):3481-4. doi: 10.1128/jb.172.6.3481-3484.1990.
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Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining region.大肠杆菌DNA促旋酶A基因中的突变扩展了喹诺酮耐药决定区。
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Antagonism between bactericidal activities of 4-quinolones and coumarins gives insight into 4-quinolone killing mechanisms.4-喹诺酮类与香豆素类杀菌活性之间的拮抗作用为深入了解4-喹诺酮类的杀菌机制提供了线索。
Microbios. 1994;77(311):121-31.

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