Obach R, Rives A, Vallés J M, Menargues A, Pruñonosa J, Vallés J
Acta Pharmacol Toxicol (Copenh). 1985 Oct;57(4):279-84. doi: 10.1111/j.1600-0773.1985.tb00043.x.
An experimental long-term hepatotoxicity study of cyanamide in Sprague-Dawley and Wistar rats has been carried out. After six months oral administration of cyanamide (2.7 and 25 mg/kg/day) no significant histological changes have been observed in the liver. Similarly, a one year intraperitoneal administration of 8 and 16 mg/kg/day has not induced any hepatic change. Specifically, no inclusion bodies in any cyanamide treated rat have been detected. Moreover, hepatic biochemical parameters have shown no significant impairment of hepatic function at doses used in human therapy (0.5-1 mg/kg).
已经对氨基氰在Sprague-Dawley大鼠和Wistar大鼠中进行了一项长期肝毒性实验研究。在口服氨基氰（2.7和25毫克/千克/天）六个月后，未观察到肝脏有明显的组织学变化。同样，腹腔注射8和16毫克/千克/天一年也未引起任何肝脏变化。具体而言，在任何接受氨基氰治疗的大鼠中均未检测到包涵体。此外，在人类治疗所用剂量（0.5-1毫克/千克）下，肝脏生化参数未显示肝功能有明显损害。
