Lawrence C E, Callanan J J, Jarrett O
Department of Veterinary Pathology, University of Glasgow, UK.
Vet Immunol Immunopathol. 1992 Dec;35(1-2):51-9. doi: 10.1016/0165-2427(92)90120-f.
We present the results of an investigation into the effects of feline immunodeficiency virus (FIV) infection on the response to mitogens and cytokine production in the first month of infection. We were able to demonstrate a depression of response of peripheral blood mononuclear cells to the mitogens concanavalin A, phytohaemagglutinin and pokeweed mitogen, with the response to pokeweed mitogen being most severely affected. The response of the cells of the spleen were affected by 10 days post infection and these could not be augmented by the addition of exogenous interleukin-2 (IL-2). The response of mesenteric lymph node cells was not affected until 20 days post infection and this could be partially restored by the addition of exogenous IL-2. IL-2 production was unaffected in peripheral blood mononuclear cells, slightly depressed in mesenteric lymph node cells and slightly elevated in spleen cells. Tumor necrosis factor levels were significantly elevated with respect to controls within 10 days of infection. These studies suggest that there are a number of changes in the immune response of FIV infected cats early in infection and this may determine the subsequent outcome of the infection.
我们展示了一项关于猫免疫缺陷病毒（FIV）感染对感染后第一个月内有丝分裂原反应和细胞因子产生影响的调查结果。我们能够证明外周血单个核细胞对有丝分裂原刀豆球蛋白A、植物血凝素和商陆有丝分裂原的反应受到抑制，其中对商陆有丝分裂原的反应受影响最为严重。感染后10天，脾脏细胞的反应受到影响，并且添加外源性白细胞介素-2（IL-2）无法增强这些反应。肠系膜淋巴结细胞的反应直到感染后20天才受到影响，并且添加外源性IL-2可使其部分恢复。外周血单个核细胞中IL-2的产生未受影响，肠系膜淋巴结细胞中略有降低，而脾脏细胞中略有升高。感染后10天内，肿瘤坏死因子水平相对于对照组显著升高。这些研究表明，FIV感染的猫在感染早期免疫反应有许多变化，这可能决定感染的后续结果。
