Ratner V A, Vasil'eva L A
Genetika. 1992 Nov;28(11):15-27.
This review is dedicated to the comparison of the facts obtained and the proposed hypotheses, to the critical analysis of the situation arisen, and to the estimation of key propositions of the concept developed. The main point is that mobile genetic elements (MGEs) participate directly in expression, variability, selection and evolution of different quantitative characters. Genetic and selection data are considered, and hypotheses of random fixation, marker effect and direct participation of MGE patterns in expression and selection of quantitative characters are discussed. The consequences of temperature treatment are considered and hypotheses of masked selection and temperature induction of transpositions are discussed. The marker effects are shown to be non-sufficient to explain the properties of quantitative character radius incompletus system. The MGE patterns are important components of genetical system of determination of a quantitative character. MGEs modify, enhance the expression of neighbouring polygenes. Temperature effects could be explained by the influence of stress temperature treatment through the system of heat shock response on the capacity of MGEs to transcribe and transpose. The system of diversed MGE patterns in drosophila chromosomes could be believed to be universal genomic system of "soft" modification of the polygenic control of any limiting quantitative characters.
本综述致力于对所获得的事实与提出的假设进行比较，对出现的情况进行批判性分析，并对所发展概念的关键命题进行评估。要点在于移动遗传元件（MGEs）直接参与不同数量性状的表达、变异性、选择和进化。考虑了遗传和选择数据，并讨论了随机固定、标记效应以及MGE模式在数量性状表达和选择中的直接参与等假设。考虑了温度处理的后果，并讨论了隐蔽选择和转座温度诱导的假设。结果表明，标记效应不足以解释数量性状半径不完全系统的特性。MGE模式是数量性状遗传决定系统的重要组成部分。MGEs修饰、增强邻近多基因的表达。温度效应可以通过热休克反应系统对应激温度处理对MGEs转录和转座能力的影响来解释。果蝇染色体中多样的MGE模式系统可被认为是对任何有限数量性状的多基因控制进行“软”修饰的通用基因组系统。
