Bonina L, Carbone M, Matera G, Teti G, Joysey H S, Hormaeche C E, Mastroeni P
Microbiology Institute, Medical School, Messina University, Italy.
J Antimicrob Chemother. 1990 May;25(5):813-23. doi: 10.1093/jac/25.5.813.
This study was undertaken to investigate the efficacy of different beta-lactam antibiotics in the treatment of systemic salmonella infections in the mouse typhoid model. Innately susceptible BALB/c (Itys) and resistant CBA (Ityr) mice were used to investigate the efficacy of one monocyclic (aztreonam) and three bicyclic (ampicillin, cefazolin, ceftazidime) beta-lactam antibiotics in controlling systemic salmonella infections when given for brief or prolonged periods. The present study confirms and amplifies earlier reports on ampicillin therapy, demonstrates marked differences in the efficacy of the different antibiotics and shows that aztreonam is not only very effective but can completely eradicate the salmonellae from the RES when given early in the infection.
本研究旨在探讨不同β-内酰胺类抗生素在小鼠伤寒模型中治疗全身性沙门氏菌感染的疗效。使用天生易感的BALB/c（Itys）小鼠和抗性CBA（Ityr）小鼠，研究一种单环β-内酰胺类抗生素（氨曲南）和三种双环β-内酰胺类抗生素（氨苄西林、头孢唑林、头孢他啶）在短期或长期给药时控制全身性沙门氏菌感染的疗效。本研究证实并扩展了早期关于氨苄西林治疗的报道，证明了不同抗生素疗效存在显著差异，并表明氨曲南不仅非常有效，而且在感染早期给药时可从网状内皮系统完全清除沙门氏菌。
