Maskell D J, Hormaeche C E
J Infect Dis. 1985 Nov;152(5):1044-9. doi: 10.1093/infdis/152.5.1044.
Relapse after cessation of ampicillin therapy in inbred mice infected with salmonellae was studied. The incidence of relapse was influenced by the following. (A) The mouse strain, with gentically susceptible animals more likely to relapse than genetically resistant animals; a possible role for the Ity gene was observed. (B) The virulence of the infecting organism, with a more virulent strain causing relapse in both resistant and susceptible mice, a less virulent strain causing relapse in neither resistant nor susceptible mice, and an intermediate strain causing relapse in susceptible mice but not in resistant mice. (C) The duration of antibiotic therapy, with prolonged treatment preventing relapse seen after short-term therapy. In all cases, ampicillin failed to clear the infection, and the mice remained carriers.
对感染沙门氏菌的近交系小鼠在氨苄青霉素治疗停止后的复发情况进行了研究。复发率受以下因素影响：（A）小鼠品系，基因易感性动物比基因抗性动物更易复发；观察到Ity基因可能发挥的作用。（B）感染生物体的毒力，毒力较强的菌株在抗性和易感性小鼠中均导致复发，毒力较弱的菌株在抗性和易感性小鼠中均不导致复发，中等毒力的菌株在易感性小鼠中导致复发但在抗性小鼠中不导致复发。（C）抗生素治疗的持续时间，长期治疗可预防短期治疗后出现的复发。在所有情况下，氨苄青霉素均未能清除感染，小鼠仍为携带者。
