Ismagilov M F, Tananov A T, Kurmyshkin A A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1992;92(5-12):35-7.
Comparison of the rate of HLA antigens I in 81 patients with frequently occurring sympathoadrenal paroxysms (SAP) associated with vegetovascular dystonia and 113 healthy subjects revealed the increase of the number of antigen B12 carriers among the patients as compared to the healthy subjects' group. The number of antigens A9, B35 in SAP patients was elevated whereas that of B18, B38 and B40 decreased. SAP related to age-associated hormonal rearrangements were marked by antigens Cw4 and A1, the grave SAP patterns by B12, SAP without nocturnal paroxysms and the early disease onset by the lack of antigen A19. The dominant gene that determines the onset of SAP is localizes in the HLA area. It may be associated with a hypothetical gene analogous to the locus implicated in the determination of the threshold of neuromuscular excitability of rats. It is not excluded that such a relationship is mediated via the blood content of Mg2+.
对81例患有与植物神经血管性肌张力障碍相关的频繁发生的交感肾上腺阵发性发作（SAP）的患者和113名健康受试者的HLA抗原I发生率进行比较，结果显示与健康受试者组相比，患者中抗原B12携带者的数量增加。SAP患者中抗原A9、B35的数量升高，而B18、B38和B40的数量减少。与年龄相关的激素重新排列相关的SAP以抗原Cw4和A1为特征，严重的SAP模式以B12为特征，无夜间阵发性发作的SAP以及疾病早期发作以缺乏抗原A19为特征。决定SAP发作的主导基因位于HLA区域。它可能与一个假设基因相关，该基因类似于参与确定大鼠神经肌肉兴奋性阈值的基因座。不排除这种关系是通过Mg2+的血液含量介导的。
