Cheng N L
Zhejiang Academy of Medical Sciences, Hangzhou.
Zhonghua Yi Xue Za Zhi. 1992 Oct;72(10):581-3, 638.
11,451 health persons were inoculated with live attenuated hepatitis A vaccine (H2 strain) in 3 batches. Among them, 785 were tested for anti-HAV antibody response by ELISA. The results showed that H2-strain vaccine got a quick antibody response (2-5 weeks) and a high seroconversion rate (92.9%). Also, the titers of antibodies to HAV ranged from 1:2 to 1:32. The seroconversion of the first 12 recipients lasted for 3 years. The primary epidemiological studies demonstrated that H2-strain vaccine was effective in preventing hepatitis A. The relation between the positive rate of antibody and different dosage showed that 10(6.5)TCID50 could get a highest seroconversion rate (100%).
11451名健康人分3批接种了甲型肝炎减毒活疫苗（H2株）。其中785人通过酶联免疫吸附测定法检测抗甲型肝炎病毒抗体反应。结果显示，H2株疫苗抗体反应迅速（2至5周）且血清转化率高（92.9%）。此外，甲型肝炎病毒抗体滴度范围为1:2至1:32。前12名接种者的血清转化持续了3年。初步流行病学研究表明，H2株疫苗在预防甲型肝炎方面有效。抗体阳性率与不同剂量之间的关系表明，10(6.5)半数组织培养感染剂量可获得最高血清转化率（100%）。
