Zhang S
Zhonghua Yi Xue Za Zhi. 1990 Dec;70(12):682-4, 48.
3089 healthy persons, aged 4 to 27 years, have been inoculated in 3 batches with attenuated live hepatitis A vaccine (H2 strain) since May, 1987. Each subject received 10(8.5) TCID dosage subcutaneously in the upper arm. None of the recipients developed any local or systemic reaction during a 42-day followup after vaccination. The serum enzyme activities, including SGPT/ALT and LDH5, were within normal range during the 4th to 16th weeks of serial tests after inoculation. The study of hepatitis A virus (HAV) shedding in feces of 4 subjects showed that no hepatitis A antigen (HAAg) was detected with antigen capture ELISA, but infectious HAV was recovered from stool-cell cultures in three of four recipients. No patient with hepatitis A was found within 6 months after vaccination in the institution where the HAV vaccine was used. In addition, no immunological evidence was seen that the HAV vaccine recipients can transmit HAV after the investigation of serological epidemiology at a class in which the HAV vaccine was tested. It is suggested that the potential of hepatitis A related to HAV vaccine among the non-vaccinated persons is rare. Seroconversion occurred at a mean time of 2 to 5 weeks after inoculation, and the positive rate of specific antibody was 95.6%.
自1987年5月以来，分3批对3089名年龄在4至27岁的健康人接种了甲型肝炎减毒活疫苗（H2株）。每位受试者在上臂皮下接种10(8.5)TCID剂量。接种疫苗后42天的随访期间，所有接种者均未出现任何局部或全身反应。接种后第4至16周的系列检测中，血清酶活性，包括SGPT/ALT和LDH5，均在正常范围内。对4名受试者粪便中甲型肝炎病毒（HAV）排出情况的研究表明，用抗原捕获ELISA未检测到甲型肝炎抗原（HAAg），但4名接种者中有3名从粪便细胞培养物中分离出了有传染性的HAV。在使用HAV疫苗的机构中，接种疫苗后6个月内未发现甲型肝炎患者。此外，在对一个班级进行甲型肝炎疫苗检测的血清流行病学调查后，没有发现免疫证据表明接种HAV疫苗的人会传播HAV。提示在未接种疫苗人群中，与HAV疫苗相关的甲型肝炎发生可能性很小。接种后血清阳转平均发生时间为2至5周，特异性抗体阳性率为95.6%。
