DZIEWIATKOWSKI D D
J Exp Med. 1957 Jan 1;105(1):69-74. doi: 10.1084/jem.105.1.69.
The thyroid glands of rats were made non-functional by a single dose of iodine-131 on the 1st day after birth or by surgical removal on the 28th day. The incorporation of sulfate-sulfur into the sulfomucopolysaccharides of skeletons and pelts was found to be significantly depressed by thyroidectomy. Daily supplements of 5 or 10 gamma of L-thyroxine, started on the 28th day, increased the uptake of sulfur-35, although it did not reach normal in the 2 weeks of treatment. Autoradiograms of sections of tibiae and pelts confirmed the analytical data. The findings suggest that the synthesis of sulfomucopolysaccharides is depressed in thyroidectomized rats.
出生后第1天给大鼠单次注射碘-131或在第28天进行手术切除，使大鼠甲状腺失去功能。结果发现，甲状腺切除显著降低了硫酸盐硫掺入骨骼和皮毛的硫酸黏多糖中的量。从第28天开始每天补充5或10微克的L-甲状腺素，可增加35硫的摄取量，尽管在2周的治疗期内未恢复到正常水平。胫骨和皮毛切片的放射自显影片证实了分析数据。这些发现表明，甲状腺切除的大鼠中硫酸黏多糖的合成受到抑制。
