Serbescu A, Păunescu E
Institutul de pneumoftiziologie Marius Nasta, Bucureşti.
Pneumoftiziologia. 1992 Jan-Mar;41(1):17-20.
The macrophage cells have an essential role in the pathogenesis of silicosis. After the endocytosis of silica grains, the lung macrophage demonstrates an active state, associated with high levels of lysosomal enzymes, expressed also in serum. A similar active state of macrophages is evident in sarcoid lung which manifests also an intensive serum activity of angiotensin-converting enzyme. The angiotensin-converting assay in the serum of 116 silicotic patients revealed over 60 per cent higher levels than in normals. Such increased levels were present more frequently among the patients with early studies of silicosis. In the same patients, the serum acid phosphatase activity, a marker of macrophage activity, and also serum lactate dehydrogenase activity, were higher than in normal individuals. On present evidence, it can be appreciated that increased serum levels of angiotensin-converting activity could be the expression of an active progressive state of silicosis.
巨噬细胞在矽肺发病机制中起重要作用。在吞噬二氧化硅颗粒后，肺巨噬细胞呈现活跃状态，伴有高水平的溶酶体酶，血清中也有表达。在结节病肺中巨噬细胞的类似活跃状态也很明显，其血清中血管紧张素转换酶活性也增强。对116例矽肺患者血清进行的血管紧张素转换检测显示，其水平比正常人高出60%以上。这种升高的水平在矽肺早期研究的患者中更常见。在同一批患者中，作为巨噬细胞活性标志物的血清酸性磷酸酶活性以及血清乳酸脱氢酶活性均高于正常个体。根据目前的证据，可以认识到血清中血管紧张素转换活性水平升高可能是矽肺活跃进展状态的表现。
