Shankland G S, Richardson M D
Department of Dermatology, University of Glasgow, UK.
Mycoses. 1992 Nov-Dec;35(11-12):329-34. doi: 10.1111/j.1439-0507.1992.tb00890.x.
In a pilot study to assess the antimycotic potential of the chemoattractant leukotriene B4 (LTB4), guinea pigs were infected with Trichophyton mentagrophytes var. mentagrophytes and divided into groups of untreated control animals or treated daily with LTB4, isoconazole nitrate or vehicle alone. The animals were assessed clinically, mycologically and histopathologically. Treatment with isoconazole nitrate was the most effective. The LTB4-treated group were clinically worse than the non-treated group and the mycological results remained positive throughout the assessment period.
在一项评估趋化因子白三烯B4（LTB4）抗真菌潜力的初步研究中，豚鼠感染须癣毛癣菌须癣变种，分为未治疗的对照组动物或每天用LTB4、硝酸异康唑或单独的赋形剂治疗的组。对动物进行临床、真菌学和组织病理学评估。硝酸异康唑治疗最为有效。LTB4治疗组在临床上比未治疗组更差，并且在整个评估期间真菌学结果仍为阳性。
