Shankland G S, Richardson M D
Mycoses. 1989 Mar;32(3):139-44. doi: 10.1111/j.1439-0507.1989.tb02222.x.
Five groups of ten guinea pigs infected with Trichophyton mentagrophytes var. mentagrophytes were evaluated in a blind study to investigate the advantages of incorporating hydrocortisone with bifonazole for the treatment of dermatophytosis. One group contained the untreated animals and the other groups were treated daily with: bifonazole alone, hydrocortisone alone, bifonazole/hydrocortisone combination or vehicle alone. The mycological, clinical and histopathological progression of the disease was monitored for three weeks. The two groups receiving the antifungal were the most impressive clinically. This was confirmed mycologically and although there was evidence of fungus on histological examination, the stratum corneum showed signs of recovery. In the three groups not receiving antifungal therapy the infection did not resolve by the end of the treatment period. Animals from these groups were mycologically positive throughout the treatment period and histological examination showed proliferation of the fungus. The groups were ranked in descending order as bifonazole/hydrocortisone combination, bifonazole alone, hydrocortisone alone, vehicle alone, untreated control.
在一项盲法研究中，对五组每组十只感染须癣毛癣菌须癣变种的豚鼠进行了评估，以研究将氢化可的松与联苯苄唑联合用于治疗皮肤癣菌病的优势。一组为未治疗的动物，其他组分别每日接受以下治疗：单独使用联苯苄唑、单独使用氢化可的松、联苯苄唑/氢化可的松联合用药或仅用赋形剂。对疾病的真菌学、临床和组织病理学进展进行了为期三周的监测。接受抗真菌治疗的两组在临床上效果最为显著。这在真菌学上得到了证实，尽管在组织学检查中有真菌存在的证据，但角质层显示出恢复的迹象。在未接受抗真菌治疗的三组中，到治疗期结束时感染仍未消退。这些组的动物在整个治疗期间真菌学检查均为阳性，组织学检查显示真菌增殖。这些组按降序排列为联苯苄唑/氢化可的松联合用药组、单独使用联苯苄唑组、单独使用氢化可的松组、仅用赋形剂组、未治疗的对照组。
