Kessler H R, Cohen R A, Lauer K, Kausch D F
Department of Psychology, Cushing Hospital, Framingham, MA 01701.
Int J Neurosci. 1992 Jan;62(1-2):17-34. doi: 10.3109/00207459108999754.
We examined the relationship between memory impairment and functional disability in multiple sclerosis. Tests of memory, sensorimotor ability, and functional capacity were administered to fifty-six subjects with chronic-progressive or remitting-relapsing MS. Sensorimotor impairment, functional disability, and chronicity predicted impairment on various measures of memory acquisition, while age and type of diagnosis did not. After accounting for the effects of initial acquisition, delayed-recall performance was weakly-associated with disability. We suggest that: (1) Functional disability is associated with memory loss in MS; (2) MS-forgetting is caused by defective acquisition, rather by a deficit in consolidation or storage; (3) Level of disease activity, rather than type of MS diagnosis, determines the degree of memory impairment; and (4) MS disability needs to be evaluated multidimensionally, to account for both neurologic and functional impairment.
我们研究了多发性硬化症中记忆障碍与功能残疾之间的关系。对56名患有慢性进展型或复发缓解型多发性硬化症的受试者进行了记忆、感觉运动能力和功能能力测试。感觉运动障碍、功能残疾和病程可预测记忆获取各项指标的损害，而年龄和诊断类型则无此作用。在考虑初始获取的影响后，延迟回忆表现与残疾的关联较弱。我们认为：（1）功能残疾与多发性硬化症中的记忆丧失有关；（2）多发性硬化症遗忘是由获取缺陷引起的，而非巩固或存储缺陷；（3）疾病活动程度而非多发性硬化症的诊断类型决定记忆损害的程度；（4）需要对多发性硬化症残疾进行多维度评估，以兼顾神经和功能损害。
