Jahnke V, Theopold H M
Laryngol Rhinol Otol (Stuttg). 1976 Aug;55(8):637-43.
The fine structure of the acute allergic reaction is described in the human nasal mucosa. Subsequent to intranasal allergic testing with positive reaction characteristic changes are seen after different time intervals: Massive transudation into the dilated intercellular spaces, loss of epithelial junctions, extrusion of epithelial cells into the nasal lumen; increase permeability of capillaries and venules with increase of fenestrations and pinocytotic vesicles, edema of the cytoplasm and dilatation of intercellular junctions in the endothelium. Characteristic for the later stages are pronounced lesions of the vessel walls with interruption of cell junctions interstitial edema. endothelial gaps and loss of endothelial cells. The endothelial basal membrane usually remains intact. The findings are compared with those described for the acute hyperergic reaction in animals and chronic allergic changes in the human nasal mucosa.
本文描述了人类鼻黏膜急性过敏反应的精细结构。在鼻内进行过敏试验且反应呈阳性后，在不同时间间隔可观察到特征性变化：大量液体渗入扩张的细胞间隙，上皮连接丧失，上皮细胞挤入鼻腔；毛细血管和小静脉通透性增加，窗孔和吞饮小泡增多，内皮细胞质水肿，细胞间连接扩张。后期的特征是血管壁明显受损，细胞连接中断，间质水肿，内皮间隙形成以及内皮细胞丧失。内皮基膜通常保持完整。将这些发现与动物急性过敏反应和人类鼻黏膜慢性过敏变化的相关描述进行了比较。
