Roa I, Araya J C, Shiraishi T, Yatani R, Wistuba I, Villaseca M, de Aretxabala X
Department of Pathology, Mie University School of Medicine, Japan.
Rev Med Chil. 1992 Dec;120(12):1351-8.
The immunohistochemical expression of pepsinogen I (PI) and pepsinogen II (PII) was studied in 103 gallbladder carcinomas, 25 non tumoral gallbladder lesions and 23 gallbladder cancer metastases. PI was positive in 6% of carcinomas and only in 2% of non tumoral contiguous mucosa. PII was positive in 46% of carcinomas and 43% of controls. Metastases were negative for both enzymes. Pyloric gland metaplasia of non tumoral mucosa adjacent to the tumor expressed PII in 68.9% and PI in 3.4% of cases. The same lesion in non tumoral gallbladders was positive for PII in 66.6% of cases, and no case expressed PI. There was no relationship between PI expression and the histological degree of differentiation. Only tumors with serosal or subserosal involvement were positive for PI. PII had a higher expression in early or well differentiated tumors. Tumors with pyloric gland metaplasia in the contiguous non tumoral mucosa expressed PII more frequently. Our results, based on the expression of PI and PII, suggest a relationship between the presence of pyloric gland metaplasia and some types of gallbladder cancer.
在103例胆囊癌、25例非肿瘤性胆囊病变及23例胆囊癌转移灶中研究了胃蛋白酶原I（PI）和胃蛋白酶原II（PII）的免疫组化表达情况。PI在6%的癌组织中呈阳性，仅在2%的非肿瘤性邻近黏膜中呈阳性。PII在46%的癌组织和43%的对照组织中呈阳性。转移灶中两种酶均为阴性。肿瘤旁非肿瘤性黏膜的幽门腺化生在68.9%的病例中表达PII，在3.4%的病例中表达PI。非肿瘤性胆囊中的相同病变在66.6%的病例中PII呈阳性，无一例表达PI。PI表达与组织学分化程度之间无相关性。仅浆膜或浆膜下受累的肿瘤PI呈阳性。PII在早期或高分化肿瘤中表达较高。邻近非肿瘤性黏膜有幽门腺化生的肿瘤更频繁地表达PII。基于PI和PII的表达，我们的结果提示幽门腺化生的存在与某些类型的胆囊癌之间存在关联。
