猫颈上神经节中的铅离子与突触传递
Lead ions and synaptic transmission in the superior cervical ganglion of the cat.
作者信息
KOSTIAL K, VOUK V B
出版信息
Br J Pharmacol Chemother. 1957 Jun;12(2):219-22. doi: 10.1111/j.1476-5381.1957.tb00123.x.
Abstract
The perfused superior cervical ganglion of the cat has been used to study the effect of lead ions on synaptic transmission and on the relase of acetylcholine from preganglionic nerve endings. Lead ions, in concentrations of 5 to 40 muM./l., caused block of ganglionic transmission, and reduced the output of acetylcholine. Calcium ions (10 mM./l.) relieved the block produced by lead ions and restored the acetylcholine output. The presence of lead ions does not seem to change the sensitivity of ganglion cells to injected acetylcholine.
摘要
猫的灌注颈上神经节已被用于研究铅离子对突触传递以及节前神经末梢乙酰胆碱释放的影响。浓度为5至40微摩尔/升的铅离子会导致神经节传递阻滞，并减少乙酰胆碱的释放量。钙离子（10毫摩尔/升）可缓解铅离子造成的阻滞，并恢复乙酰胆碱的释放量。铅离子的存在似乎并未改变神经节细胞对注入乙酰胆碱的敏感性。
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