Michelot D
Laboratoire de Chimie, U.R.A. 401 du C.N.R.S., Muséum National d'Histoire Naturelle, Paris, France.
Nat Toxins. 1992;1(2):73-80. doi: 10.1002/nt.2620010203.
The ink cap--Coprinus atramentarius (Bulliard ex Fries) Fries--is responsible for poisoning when ingested with alcohol. The investigation of the "Coprinus syndrome," although a minor poisoning incident, stimulated numerous research programs because the results were expected to yield a novel drug useful during the treatment of alcoholism. This work led to the identification of the active principle--coprine--and to an explanation of its mode of action; nevertheless, detailed toxicology investigations have shown that the mutagenic and gonadotoxic properties of this compound made it unsuitable for therapeutic use. Our current knowledge of the poisoning, the chemistry of the toxin, and its mode of action are here reviewed.
墨汁鬼伞——粪生鬼伞（弗里氏粪生鬼伞）——与酒精一同摄入时会导致中毒。对“墨汁鬼伞综合征”的研究，尽管是一起轻微中毒事件，却激发了众多研究项目，因为预期研究结果会产生一种在治疗酒精中毒时有用的新型药物。这项工作促成了活性成分——鬼伞素——的鉴定及其作用方式的解释；然而，详细的毒理学研究表明，该化合物的致突变和性腺毒性特性使其不适合用于治疗。本文综述了我们目前对该中毒现象、毒素化学及其作用方式的认识。
