Honjo H, Tanaka K, Urabe M, Naitoh K, Ogino Y, Yamamoto T, Okada H
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Japan.
Clin Ther. 1992 Sep-Oct;14(5):699-707.
In study 1, serum lipid and estrogen levels were determined in 30 women (aged 40 to > 60 years). Total cholesterol (TC) levels increased significantly with age, but no significant association was found between TC levels and menopausal status. Hypercholesterolemia (TC > 220 mg/dl) was identified in 10 women and hypertriglyceridemia (> 150 mg/dl) in 5 women. Among women not receiving estrogen replacement therapy, a significant negative correlation was found between TC levels and estradiol-17 beta levels. In study 2, serum lipid and estrogen levels were determined in 74 women; 12 of the 74 were receiving conjugated estrogen for the treatment of the menopausal syndrome and 21 hyperlipidemic women were receiving pravastatin (2.5 to 30 mg daily). Among postmenopausal women, high-density lipoprotein cholesterol levels were significantly higher and low-density lipoprotein (LDL) cholesterol levels significantly lower in the estrogen-treated than untreated women. Serum TC and LDL cholesterol levels were significantly reduced during pravastatin treatment. Levels of endogenous estrogens (estradiol-17 beta, estrone, and estrone sulfate) were not significantly affected by pravastatin treatment. The results indicate that pravastatin can be used to reduce hyperlipidemia in menopausal women without affecting endogenous estrogen levels.
在研究1中，对30名年龄在40至60岁以上的女性测定了血脂和雌激素水平。总胆固醇（TC）水平随年龄显著升高，但未发现TC水平与绝经状态之间存在显著关联。10名女性被诊断为高胆固醇血症（TC>220mg/dl），5名女性为高甘油三酯血症（>150mg/dl）。在未接受雌激素替代疗法的女性中，发现TC水平与雌二醇-17β水平之间存在显著负相关。在研究2中，对74名女性测定了血脂和雌激素水平；74名中有12名正在接受结合雌激素治疗绝经综合征，21名高脂血症女性正在接受普伐他汀治疗（每日2.5至30mg）。在绝经后女性中，接受雌激素治疗的女性高密度脂蛋白胆固醇水平显著高于未接受治疗的女性，低密度脂蛋白（LDL）胆固醇水平显著低于未接受治疗的女性。普伐他汀治疗期间血清TC和LDL胆固醇水平显著降低。普伐他汀治疗对内源性雌激素（雌二醇-17β、雌酮和硫酸雌酮）水平无显著影响。结果表明，普伐他汀可用于降低绝经后女性的高脂血症，而不影响内源性雌激素水平。
