O'Donnell L J, Wilson P, Guest P, Catnach S M, McLean A, Wickham J E, Fairclough P D
Department of Gastroenterology, St Bartholomew's Hospital, West Smithfield, London, UK.
Lancet. 1992 Feb 1;339(8788):269-71. doi: 10.1016/0140-6736(92)91333-4.
Patients with gallstone disease commonly have impaired gallbladder emptying. To see whether non-steroidal anti-inflammatory drugs (NSAIDs) prevent gallstone formation by improving gallbladder emptying, we assessed the effect of indomethacin on postprandial emptying in healthy subjects and in patients with gallstone disease. Subjects received indomethacin 25 mg three times a day for a week and matching placebo for another week. Compared with placebo, indomethacin improved postprandial gallbladder emptying in all 7 patients with gallstone disease. This finding was not recorded in healthy subjects with normal gallbladders. The prevention of gallstone formation associated with ingestion of NSAIDs may be due mainly to a prokinetic effect on the gallbladder since there is no evidence to suggest that these drugs affect cholesterol crystal nucleation at ordinary therapeutic doses in man or animals.
患有胆结石疾病的患者通常存在胆囊排空功能受损的情况。为了探究非甾体类抗炎药（NSAIDs）是否通过改善胆囊排空来预防胆结石形成，我们评估了吲哚美辛对健康受试者和胆结石疾病患者餐后胆囊排空的影响。受试者每天服用三次25毫克吲哚美辛，持续一周，然后服用匹配的安慰剂一周。与安慰剂相比，吲哚美辛改善了所有7例胆结石疾病患者的餐后胆囊排空。在胆囊正常的健康受试者中未观察到这一现象。与摄入NSAIDs相关的胆结石形成预防作用可能主要归因于其对胆囊的促动力作用，因为没有证据表明这些药物在人或动物的常规治疗剂量下会影响胆固醇晶体成核。
