Das A, Baijal S S, Saraswat V A
Department of Gastroenterology and Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Dig Dis Sci. 1995 Aug;40(8):1782-5. doi: 10.1007/BF02212702.
Patients with gallstone disease have impaired gallbladder motility. Prostaglandins are thought to be important mediators of gallbladder hypomotility. We assessed the effect of aspirin, a prostaglandin inhibitor on gallbladder resting volume and ejection fraction according to a double-blind study protocol in 20 healthy volunteers and 30 patients with gallstone disease. Healthy volunteers had a higher ejection fraction compared to patients with gallstone disease (73.9 +/- 0.9% vs 60.4 +/- 1.0%, P < 0.05). Aspirin in a dose of 350 mg/day for two weeks did not alter gallbladder motility in the healthy volunteers. Thirty patients with gallstone disease were randomized into three treatment groups: group I (placebo), group II (aspirin 350 mg/day), and group III (aspirin 1400 mg/day). After two weeks of treatment, gallbladder ejection fraction was improved in group II (74.0 +/- 1.7% vs 62.0 +/- 1.7%, P < 0.01) and group III (69.8 +/- 3.8% vs 61.2 +/- 1.3%, P < 0.01) but not in group I (60.4 +/- 2.6% vs 59.0 +/- 1.9%, P = NS). The higher dose of aspirin did not induce a greater increase in gallbladder emptying. It is concluded that impaired gallbladder motility in patients with gallstone disease is corrected by short-term oral aspirin even in low dosage. This may be clinically useful in secondary prophylaxis after nonsurgical therapy for gallstone disease.
胆结石疾病患者的胆囊动力受损。前列腺素被认为是胆囊动力不足的重要介质。我们根据双盲研究方案，评估了前列腺素抑制剂阿司匹林对20名健康志愿者和30名胆结石疾病患者胆囊静息容积和射血分数的影响。与胆结石疾病患者相比，健康志愿者的射血分数更高（73.9±0.9%对60.4±1.0%，P<0.05）。健康志愿者连续两周每天服用350毫克阿司匹林并未改变胆囊动力。30名胆结石疾病患者被随机分为三个治疗组：第一组（安慰剂）、第二组（每天350毫克阿司匹林）和第三组（每天1400毫克阿司匹林）。治疗两周后，第二组（74.0±1.7%对62.0±1.7%，P<0.01）和第三组（69.8±3.8%对61.2±1.3%，P<0.01）的胆囊射血分数有所改善，但第一组（�0.4±2.6%对59.0±1.9%，P=无显著性差异）没有改善。较高剂量的阿司匹林并未使胆囊排空增加更多。结论是，即使是低剂量的短期口服阿司匹林也能纠正胆结石疾病患者受损的胆囊动力。这在胆结石疾病非手术治疗后的二级预防中可能具有临床应用价值。
