Nöthen M M, Erdmann J, Körner J, Lanczik M, Fritze J, Fimmers R, Grandy D K, O'Dowd B, Propping P
Department of Psychiatry, University of Bonn, Germany.
Am J Psychiatry. 1992 Feb;149(2):199-201. doi: 10.1176/ajp.149.2.199.
Fifty-six patients with bipolar affective disorder and 69 healthy control subjects were tested for association of restriction fragment length polymorphism alleles at the dopamine D1 and D2 receptor loci. No significant associations were found; thus, the hypothesis that a single mutant form of either receptor gene is responsible for the phenotype of patients with bipolar affective disorder was not supported.
对56名双相情感障碍患者和69名健康对照者进行检测，以研究多巴胺D1和D2受体基因座上的限制性片段长度多态性等位基因的关联性。未发现显著关联；因此，双相情感障碍患者的表型由任一受体基因的单一突变形式所致这一假设未得到支持。
