Nakazawa A, Inoue M, Saito J, Sasagawa T, Ueda G, Tanizawa O
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
Int J Gynaecol Obstet. 1992 Jan;37(1):13-8. doi: 10.1016/0020-7292(92)90972-l.
We applied the polymerase chain reaction (PCR) to detect HPV 16 and 18 in cytological samples obtained from the uterine cervices of Japanese women. HPV infection was detected in 17 (25%) of 67 with CIN and 11 (37%) of 30 with cervical carcinoma. It is notable that 11 (16%) of 69 women with normal cervices were infected with either HPV 16 or 18. The polymerase chain reaction is sensitive and useful for epidemiological studies.
我们应用聚合酶链反应（PCR）检测从日本女性子宫颈获取的细胞学样本中的人乳头瘤病毒16型（HPV 16）和18型（HPV 18）。在67例宫颈上皮内瘤变（CIN）患者中，有17例（25%）检测到HPV感染；在30例宫颈癌患者中，有11例（37%）检测到HPV感染。值得注意的是，69例宫颈正常的女性中有11例（16%）感染了HPV 16或HPV 18。聚合酶链反应对于流行病学研究来说灵敏且实用。
