Nakazawa A, Inoue M, Fujita M, Tanizawa O, Hakura A
Department of Obstetrics and Gynecology, Osaka University Medical School.
Jpn J Cancer Res. 1991 Nov;82(11):1187-90. doi: 10.1111/j.1349-7006.1991.tb01777.x.
The polymerase chain reaction (PCR) was employed to detect human papillomavirus (HPV) 16 and 18 in cytological samples from the uterine cervix and in urine samples from the male consorts. HPV 16 was detected in 2 (25%) of 8 males whose wives were positive for HPV 16, while it was detected in only one (7%) of 14 consorts whose wives were negative for HPV 16 and 18. This is the first report of the detection of HPV 16 in urine. Viral detection in urine samples by the PCR method is a non-invasive, convenient and useful tool for large-scale epidemiologic studies and investigations of the mechanism of virus transmission.
采用聚合酶链反应(PCR)检测子宫颈细胞学样本及男性配偶尿液样本中的人乳头瘤病毒(HPV)16和18型。在妻子HPV 16呈阳性的8名男性中,有2名(25%)检测出HPV 16,而在妻子HPV 16和18均呈阴性的14名配偶中,仅1名(7%)检测出HPV 16。这是尿液中检测出HPV 16的首次报道。通过PCR方法检测尿液样本中的病毒是一种用于大规模流行病学研究及病毒传播机制调查的非侵入性、便捷且有用的工具。