Balldin J I, Berggren U C, Lindstedt G
Department of Psychiatry and Neurochemistry, University of Göteborg, Sweden.
Alcohol Clin Exp Res. 1992 Feb;16(1):71-4. doi: 10.1111/j.1530-0277.1992.tb00639.x.
Postsynaptic dopamine (DA) receptor sensitivity was assessed during abstinence in 15 male patients with alcohol dependence. The DA receptor sensitivity was evaluated using growth hormone (GH) responses to the DA receptor agonist apomorphine (0.18-0.24 mg intravenously). The patients were cared for in an alcoholism treatment unit for the 2 months prior to the investigation. They were carefully controlled for sobriety during this period. Thirteen healthy men were used as controls. The maximum GH responses to apomorphine were significantly reduced in patients compared with those in the control group. The patients had a significantly higher proportion of blunted GH responses. The findings suggest reduced postsynaptic DA, possibly D2, receptor sensitivity in abstinent alcoholics. The question whether this abnormal DA receptor status is genetically determined or acquired after long-term alcohol consumption remains to be addressed.
对15名酒精依赖男性患者戒酒期间的突触后多巴胺（DA）受体敏感性进行了评估。使用生长激素（GH）对DA受体激动剂阿扑吗啡（静脉注射0.18 - 0.24毫克）的反应来评估DA受体敏感性。在调查前的2个月里，患者在酒精中毒治疗单元接受护理。在此期间，对他们的清醒状态进行了严格监控。13名健康男性作为对照。与对照组相比，患者对阿扑吗啡的最大GH反应显著降低。患者中GH反应迟钝的比例显著更高。研究结果表明，戒酒的酗酒者突触后DA（可能是D2）受体敏感性降低。这种异常的DA受体状态是由基因决定的还是长期饮酒后获得的，这个问题仍有待解决。
