Yu C C, Fletcher C D, Newman P L, Goodlad J R, Burton J C, Levison D A
Department of Histopathology, UMDS, Guy's Hospital, London, U.K.
J Pathol. 1992 Feb;166(2):147-52. doi: 10.1002/path.1711660210.
Gastrointestinal stromal tumours are lesions in which it is difficult to predict clinical outcome from the histological appearances. Sixty cases were studied using three different methods of assessing aspects of cellular proliferation; these were (i) immunostaining for proliferating cell nuclear antigen (PCNA), (ii) interphase nucleolar organizer region staining (AgNORs), and (iii) a histological grading system based on mitotic counts. Both PCNA immunostaining and AgNOR counts were found to correlate well with histological grading and all three methods independently showed good correlations with survival. This suggests that these proliferation-associated markers may be used as additional features to support histological grading in this relatively uncommon group of tumours.
胃肠道间质瘤是一种难以根据组织学表现预测临床结果的病变。使用三种不同的方法评估细胞增殖的各个方面对60例病例进行了研究；这些方法分别是：（i）增殖细胞核抗原（PCNA）免疫染色，（ii）间期核仁组织区染色（AgNORs），以及（iii）基于有丝分裂计数的组织学分级系统。发现PCNA免疫染色和AgNOR计数均与组织学分级密切相关，并且所有三种方法均独立显示与生存率有良好的相关性。这表明这些与增殖相关的标志物可作为额外的特征，以支持对这一相对罕见的肿瘤组进行组织学分级。
