Padros M R, Noli M I, Fainboim L
Laboratorio de Immunogenética, Hospital de Clinicas José de San Martin, Facultad de Medicina, Buenos Aires, Argentina.
Clin Exp Immunol. 1992 May;88(2):329-34. doi: 10.1111/j.1365-2249.1992.tb03082.x.
Peripheral blood normal B lymphocytes were found to be poor stimulators in the mixed lymphocyte reaction (MLR), in contrast to normal activated B cells which were strong stimulators. This increased capacity to stimulate a strong MLR correlated with an increased expression of the ICAM-1 (CD54) molecule on the surface of these cells. Similarly, the capacity of leukaemic B cells to induce an allogenic stimulation in the MLR was limited to the ICAM-1 (CD54) positive leukaemic cells. The ability of normal activated or leukaemic B cells to induce an MLR was blocked by antibodies directed against ICAM-1.
与正常活化B细胞（强刺激细胞）相比，外周血正常B淋巴细胞在混合淋巴细胞反应（MLR）中是弱刺激细胞。这些细胞刺激产生强烈MLR的能力增强，与细胞表面ICAM-1（CD54）分子表达增加相关。同样，白血病B细胞在MLR中诱导同种异体刺激的能力仅限于ICAM-1（CD54）阳性的白血病细胞。针对ICAM-1的抗体可阻断正常活化B细胞或白血病B细胞诱导MLR的能力。
